Israel’s military says Iranian forces have fired rockets at its positions in the occupied Golan Heights.
It said around 20 rockets were fired by Iran’s Revolutionary Guard early on Thursday and some were intercepted, adding that there were no casualties.
Earlier this week, Israel said it had noted “irregular activity” by Iranian forces in the region.
It placed its troops in the Golan Heights on high alert and urged civilians to take shelter.
The Israel Defense Forces (IDF) later said it had targeted dozens of Iranian facilities with air strikes in retaliation for the attack.
Syria’s state news agency Sana said Israeli missiles had been shot down south of Homs, but reported that a weapons depot and air defence positions had been hit.
The latest confrontation follows a reported Israeli missile strike on a military outpost south of the Syrian capital of Damascus on Tuesday.
Sana reported that two missiles were shot down in the Kiswah area and that two civilians were killed in an explosion.
But the Syrian Observatory for Human Rights, a UK-based monitoring group, said the missiles hit an Iranian weapons depot, killing 15 pro-government fighters.
Eight members of Iran’s powerful Revolutionary Guards force and several other non-Syrian nationals were among those killed, it said.
Israel did not comment on the reports, but its government has vowed to stop what it considers Iran’s military “entrenchment” in Syria.
Iran is a Syrian ally and has deployed hundreds of troops to the country.
Thousands of militiamen armed, trained and financed by Iran – mostly from Lebanon’s Hezbollah movement, but also Iraq, Afghanistan and Yemen – have also been fighting alongside the Syrian army.